• AON successfully alleviated the myotonic phenotype in DM mod

  2019-07-13

  AON successfully alleviated the myotonic phenotype in DM model mice [18], [23]. To screen for an optimal AON sequence, we used 25-mer phosphorothioate 2′ O-methyl RNA molecules that covered the exon 6B or exon 7A.

• Two key enzymes play important roles

  2019-07-12

  Two key enzymes play important roles in the bioconversion of xylitol from d-arabitol, namely d-arabitol dehydrogenase (ArDH) and NADH-dependent xylitol dehydrogenase (XDH), respectively (Qi et al., 2014).

• Introduction In addition to

  2019-07-11

  Introduction In addition to the canonical double stranded structure, DNA can form various higher order structures such as bulges, and various kinds of mismatches, triplexes, to the G-quadruplex (G4).

• Signaling of DDR receptor and

  2019-07-10

  Signaling of DDR2 receptor and its regulation Being the tyrosine kinase receptor, downstream signaling of DDR2 receptor is initiated by phosphorylation of cytoplasmic tyrosine residue upon ligand binding (Type II collagen) but the authentic facts or detail information of tyrosine phosphorylation upon the binding of collagen protein is not still clear to the researcher.

• A robust meta analysis of randomized clinical

  2019-07-09

  A robust meta-analysis of 22 randomized clinical trials found that application of ischemic preconditioning strategies reduce ventricular arrhythmias [3].

• vitamin D binding protein precrusor (208-218) [Homo sapiens]

  2019-07-08

  It is not precisely known which of the intramolecular interactions created by the SH2 domain, the SH3–SH2 linker and the SH2–kinase linker are essential for the catalytic activity of Csk or how these interactions regulate Csk activity.

• Conclusion In this review we

  2019-07-05

  Conclusion In this review, we have discussed how inhibition of the CK2/CDK5 signaling axis protects WM only when inhibited before ischemia, while inhibition of the CK2/AKT/GSK3β signaling axis protects WM either before or after an ischemic injury in young, aging, and old WM (Fig. 3).

• In summary the loss of seven Cyp a genes lead

  2019-07-04

  In summary, the loss of seven Cyp3a genes lead to sexual dimorphic changes during the eight weeks of high fat diet treatment with Cyp3a-null female mice showing a healthier acclimation to a high fat diet through decreased weight gain, higher adiponectin, lower B-OHB levels, and a better response to glucose; while the Cyp3a-null males succumb to increased fatty liver including slightly increased weight, higher hepatic polar lipids and triglycerides, and greater liver weight.

• In vitro studies suggest that cPLA does not

  2019-07-03

  In vitro studies suggest that cPLA2α does not show clear preference for the headgroup present at the sn-3 position, although a slight preference for zwitterionic phospholipids such as PC and PE has recently been pointed out [24].

• We postulate that OT contained

  2019-07-02

  We postulate that OT contained in milk during early postnatal development causes a mild enteroprotective preconditioning of the ER (Fig 9).

• ARA metabolites which are produced through

  2019-07-01

  ARA metabolites, which are produced through cytochrome P450 (CYP450) enzymes influence cardiovascular homeostasis.

• Some health related topics are guaranteed to

  2019-06-29

  Some health-related topics are guaranteed to stir up heated debate in the general public whenever they LEP (116-130) (mouse) crop up in the news.

• Holter ECG monitoring was performed after the

  2019-06-28

  Holter ECG monitoring was performed after the patient consumed 180mL of sake (alcohol) each night in both the DDD-R and DDD-CLS modes. The mean HR in the DDD-CLS mode (68bpm) was similar to that (71bpm) in the DDD-R mode, but during sleep, the atrial pacing ratio (43.2%) in DDD-CLS was significantly higher than that (7.4%) in the DDD-R mode (p<0.001).

• br With respect to the

  2019-06-27

  With respect to the welfare of children and mothers, the transition from the Millennium Development Goals (MDGs) to Sustainable Development Goals (SDGs) is sometimes perceived as risky.

• br Rheumatic heart disease RHD affects over million

  2019-06-27

  Rheumatic heart disease (RHD) affects over 32 million people worldwide; the vast majority of patients are in low-income and middle-income countries.

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