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br UVC induced DNA damage
2019-09-29
UVC-induced DNA damage: a model to study DNA damage tolerance The UV components of sunlight that reaches the Earth surface are one of the most carcinogenic agents humans are exposed to, and the leading cause of skin cancer [4,12]. UV light causes different types of DNA damage through indirect and
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Here we uncover a highly diverse
2019-09-29
Here we uncover a highly diverse superfamily of self-replicating MGEs, dubbed pipolins, which are present in three major bacterial phyla, as well as in mitochondria, and encode divergent PolB carrying TPR1 and TPR2 subdomains. Biochemical characterization of a representative enzyme encoded by a pipo
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We have reported previously that aminoacrylate
2019-09-29
We have reported previously that β-aminoacrylate derivatives of the general structure () are inhibitors of DHODH. In particular, tricyclic derivatives and displayed sub-micromolar IC values against DHODH, and in the case of there was a 1000-fold greater potency compared to the human enzyme (DHOD
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Acknowledgments We are grateful to Dr Jean Marie Bernassau
2019-09-29
Acknowledgments We are grateful to Dr. Jean-Marie Bernassau for his leadership in establishing our virtual screening platform and Dr. Julie Bick for protein purification. X-ray data collection for compound 4 was performed by Shamrock Structures at Southeast Regional Collaborative Access Team (SER-C
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Aldehyde dehydrogenase has been characterized as
2019-09-29
Aldehyde dehydrogenase has been characterized as a cancer stem cell marker, which plays a key role in various biological processes in tumor, including cell proliferation, invasiveness and chemoresistance. Recent data of Abourbih et al reported that ALDH1 expression did not correlate with primary tum
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3,3\',5\'-Triiodo-L-thyronine and In this paper we f
2019-09-27
In this paper, we focused on Ewing sarcoma (ES), a rapidly growing, highly malignant bone tumor developing metastases in the vast majority of patients unless multiagent chemotherapy is applied [16]. ES is the second most frequent bone tumor in childhood and adolescence, and is characterized by the p
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br Conflicts of interest br Acknowledgements br Introduction
2019-09-27
Conflicts of interest Acknowledgements Introduction Atherosclerosis is the number one cause of death in the United States and among the leading causes of morbidity and mortality globally [1]. Inflammation is critical in all stages of atherosclerosis from the formation of a plaque in the ves
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E7080 The biological significance of DNA ligases is attribut
2019-09-27
The biological significance of DNA ligases is attributed to their function in DNA replication, recombination and/or DNA repair [1], [2]. In vertebrates, three different DNA ligases I, III and IV are recognized. DNA ligase I is essential for the Okazaki fragments’ ligation during lagging-strand DNA s
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Previous synthetic lethal screening efforts Cox et al have
2019-09-27
Previous synthetic lethal screening efforts (Cox et al., 2014) have mainly used RNAi as a means of identifying potential targets (Barbie et al., 2009, Kim et al., 2016, Luo et al., 2009, Scholl et al., 2009), although a few screens (Shaw et al., 2011, Steckel et al., 2012) have been performed with s
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In Senegal malaria remains a formidable public health issue
2019-09-27
In Senegal, malaria remains a formidable public health issue, causing significant morbidity and mortality in infants and pregnant women (WHO Malaria Report, 2012). In the absence of an effective vaccine, the National Malaria Control Program has followed WHO recommendations for IPTp-SP since 2003. Th
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We examined the function of
2019-09-27
We examined the function of immobilised THPs by seeding cells transfected with DDR2-Flag on derivatised crosslinked collagen films, then detecting the phosphorylation of tyrosine 740 (Y740) on the intracellular domain of DDR2 [50]. This regulatory residue is a target for the intracellular tyrosine k
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Among the various neurotransmitter systems pointed out to pl
2019-09-27
Among the various neurotransmitter systems pointed out to play a role in the mediation of defensive and antinociceptive responses elicited by environmentally aversive stimuli, the neuropeptide corticotropin-releasing factor or hormone (CRF or CRH) has attracted the interest of many researchers inves
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POE specialises Rogers definition of engineering to systems
2019-09-27
POE specialises Rogers\' definition of engineering [37] to systems engineering as: As such, systems engineering becomes a problem solving exercise, the problem being, given a physical environment E, to find the system S that Emodepside meets a real-world need N to the satisfaction of a group of sta
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Notochord is a transient structure differentiating at
2019-09-27
Notochord is a transient structure differentiating at early stage during embryogenesis that is at the origin of vertebral bodies in all vertebrates. In zebrafish, it is composed of vacuolated Dabrafenib surrounded by a unique ECM structure improperly called notochordal BM. As in chicken and amphibi
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The swelling independent activation of chloride
2019-09-27
The swelling-independent activation of chloride channels by glycerol is proved by our further experiments. When glycerol concentration in the isoosmotic solution was reduced to the micromolar scale or even lower concentration, a Cl− current was still induced. The reverse transcriptase were not swol
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