• It was recently reported that a functional single nucleotide

  2021-02-10

  

  It was recently reported that a functional single nucleotide polymorphism (rs75932628) within Triggering receptor expressed on myeloid 2-Chlorotrityl Chloride Resin mg 2 (TREM2) is associated with AD (Guerreiro et al., 2013). Homozygous loss of function mutations in TREM2 are also associated with a

• Some studies have integrated the use of cloud

  2021-02-10

  

  Some studies have integrated the use of cloud computing with user interfaces in the domain of our proposal (i.e. UI). In [24] the authors work with Android devices to achieve more flexibility in the user interfaces by making use of information about the environment (for example, with an ambient ligh

• Other studies have investigated the role of HDAC

  2021-02-09

  

  Other studies have investigated the role of HDAC inhibitors in particular signaling pathways mediated by EWS–FLI1 (Matsumoto et al., 2001). A recent investigation, showed a physical association of EWS–FLI1 and HDAC1 that helps mediate a disruption in the p53 activation of downstream targets (Li et a

• For the current studies we

  2021-02-09

  

  For the current studies, we used the selective Epac agonist 8CPT-AM to directly activate the proteins. We chose this pharmacological approach since it allows a direct activation of Epacs rather than using receptor agonists such as PGE2 which could introduce confounding variables. One potential conce

• In the course of this study K PFOS

  2021-02-09

  

  In the course of this study, K+PFOS did not appear to have any effect on the thyroid parameters evaluated (H&E histology, follicular epithelial cell proliferation, and follicular epithelial apoptosis). This is an interesting observation considering the fact that treatment with K+PFOS resulted in act

• Nimodipine administration also inhibited the eIF ATF singnal

  2021-02-09

  

  Nimodipine administration also inhibited the eIF2α/ATF4 singnaling which is a crucial evolutionarily conserved adaptive pathway during cellular stresses including hypoxia and ischemia (Evans et al., 2016; Manwani and McCullough, 2013). While, the eIF2a/ATF4 pathway, activated by different forms of s

• The relatively less well studied encodes the E type

  2021-02-09

  

  The relatively less well-studied encodes the E2 type SUMO-conjugating enzyme. In plants, the SCE family members play roles in abiotic stress responses. An E2 enzyme, SaSce9, from plays roles in salinity and drought stress responses (). Furthermore, SCE can respond to heat stress in rice (). However,

• br STAR Methods br Acknowledgments We thank the City

  2021-02-09

  

  STAR★Methods Acknowledgments We thank the City of Hope core facilities, including the Animal Model Core, Bioinformatic Core, NMR Core, Flow Cytometry Core, and Florescence Microscopy Core for excellent technical support, and NIH grants R01GM086171, R01GM102538, and R01CA212119, R01CA216987, an

• carboxypeptidase a In conclusion we have found that Egr can

  2021-02-09

  

  In conclusion, we have found that Egr1 can play an inhibitory role on DBH promoter-driven transcription. This inhibition requires a newly identified Egr1 response carboxypeptidase a at the −227/−224 region of DBH promoter. This inhibition appears to result from Egr1 directly bound to the DBH promot

• The number of DBH alleles affects dopamine and norepinephrin

  2021-02-09

  

  The number of DBH Cholera Toxin synthesis affects dopamine and norepinephrine levels in the prefrontal cortex of mice when they are treated with disulfiram (33). Disulfiram increased dopamine and decreased norepinephrine levels in their prefrontal cortex of mice with two normal alleles, whereas dis

• One of the hallmarks of the

  2021-02-09

  

  One of the hallmarks of the terminal stages of apoptosis is the fragmentation of chromosomal DNA that proceeds in a two-step manner: the DNA is initially cleaved into 50–300kb fragments and eventually into oligonucleosomal pieces [12], [13]. The two major apoptotic nucleases are DNA fragmentation fa

• Our results indicate a deregulation

  2021-02-09

  

  Our results indicate a deregulation of DNA methylation machinery during seed development in apomixis. Since DRM2 is targeted loci through an RNA-directed DNA methylation (RdDM) pathway involving 24-nt siRNAs (Stroud et al., 2014, Law and Jacobsen, 2010) and differentially expressed between apomict a

• DGK deficiency caused a significant increase in

  2021-02-09

  

  DGKδ deficiency caused a significant increase in the SERT protein level, but its mRNA level was not affected (Fig. 1). These results suggest that SERT protein stability is directly reduced by interaction with the DGKδ protein. In contrast, DGKδ deficiency regulated both TPH-2 and MAO-A protein and m

• The first transcription factor TF known

  2021-02-09

  

  The first transcription factor (TF) known to interact with one of the cis-acting GAREs is GAMYB protein, the expression of which is induced by GA in the aleurone nicotinic receptors of barley (HvGAMYB) (Gubler and Jacobsen, 1992). GAMYB is an important regulator of endosperm functions during seed d

• A more refined picture of cholinesterase activity patterns

  2021-02-09

  

  A more refined picture of cholinesterase activity patterns may be obtained by measuring ChE activity of the same sample before and after addition of certain cholinesterase inhibitors, with differential specificity for different components of total ChE activity, such as BW284c51 (BW1,5-bis-(4-allyldi

15035 records 698/1003 page Previous Next First page 上5页 696697698699700 下5页 Last page