• br Results and discussion Analysis of experimental data indi

  2021-01-22

  

  Results and discussion Analysis of experimental data indicates that the radon Torin1 coefficient in OPC blended with RHA varies from 0.15 × 10−6 m2 s−1 for pure cement to 0.26 × 10−6 m2 s−1 for cement mixed with 50% RHA by weight. The value of diffusion coefficient first decreases in cement with

• Although BPA has been proven to

  2021-01-22

  

  Although BPA has been proven to cause many health issues such as obesity and neurological toxicity (Rubin, 2011), the effects and mechanisms of BPA on the human tumorigenesis and cancer development are still not well illustrated. In the present study, we found that 10 to 10M BPA significantly promot

• br Introduction Rhabdomyosarcoma RMS is a myogenic tumor tha

  2021-01-22

  

  Introduction Rhabdomyosarcoma (RMS) is a myogenic tumor that accounts for approximately 50% of all pediatric soft tissue sarcomas. Diagnostic criteria for RMS pitavastatin on the validation of proteins of the skeletal muscle lineage, such as Desmin, MyoD or Myogenin [1]. RMS cells are persistent

• In particular EphB has been one of the

  2021-01-22

  

  In particular, EphB4 has been one of the most studied receptor of the Eph family: inhibition of EphB4 expression using interfering-RNA or antisense oligonucleotides inhibited proliferation, survival and invasion of PC3 prostate cancer GSK 2830371 in vitro and in vivo. Inhibition of EphB4 signalling

• In our study the TIP P model is applied

  2021-01-22

  

  In our study, the TIP3P model is applied for water, AMBER99sb force field [24] is used to describe three types of EGFR, including the wild type (PDB: 2ITY) [25], its mutant G719S (PDB: 2ITO) [25] and mutant T790M (PDB: 3IKA) [26]. The force field of Tubemoside molecule is parameterized with optimize

• br Acknowledgments br Introduction Ubiquitin ligases limit t

  2021-01-22

  

  Acknowledgments Introduction Ubiquitin ligases limit the stability and activity of substrates by targeting them for proteasomal-dependent degradation. Siah is a two-member family of ubiquitin ligases implicated in control of key cellular processes. Among those, Siah ligases control prolyl hydr

• High throughput screening HTS of the AstraZeneca

  2021-01-21

  

  High throughput screening (HTS) of the AstraZeneca Amyloid Beta-Peptide (1-40) australia collection was conducted and identified oxadiazole amide () originating from a kinase directed screening library (although inactive against a panel of kinases). This compound had moderate potency as a DGAT-1 i

• br Cytokine profile in MPN

  2021-01-21

  

  Cytokine profile in MPN: Results from experimental investigation Cytokines are small molecules constituted by proteins or glycoproteins, which regulate the immune cell function and the immune system. They are secreted mainly by immune tgf beta receptor 1 but also by other cells such as epithelial

• br Materials and methods br Results br

  2021-01-21

  

  Materials and methods Results Discussion In this study, we developed a new CysLT1 and CysLT2 receptors-mediated Aprotinin guinea pig model for screening both CysLT2 receptor and CysLT1/2 receptor antagonists. Unlike human CysLT2 receptors, which are equally stimulated by both LTC4 and LTD4

• br Conclusion br Introduction Interleukin IL is a

  2021-01-21

  

  Conclusion Introduction Interleukin (IL)-18 [1] is a member of the IL-1 cytokine family activating corner stones of inflammatory signaling, among others nuclear factor (NF)-κB and p38 mitogen-activated protein kinase. Striking similarities exist between IL-1β and IL-18 including processing by

• Therefore the relationship between ChEs activity and

  2021-01-21

  

  Therefore, the relationship between ChEs activity and polymorphisms in POT1, TERF1, TERT genes were explored in order to screen susceptible biomarkers in this study. Materials and methods Results Discussion However, genetic toxicity induced by OPs has not been fully investigated so far. Ca

• br Benefits and risks of traditional

  2021-01-21

  

  Benefits and risks of traditional combined oestrogen–progestogen HRT regimens Combined oestrogen–progestogen regimens were developed to reproduce the short- and long-term benefits of oestrogen replacement therapy (ERT) and to simultaneously provide appropriate protection against oestrogen-related

• SS is a high grade malignant soft tissue sarcoma accounting

  2021-01-21

  

  SS is a high-grade malignant soft tissue sarcoma accounting for 5%–10% of soft tissue sarcomas. After RMS, SS is the most common sarcoma in children, adolescents and young adults [9]. SS originates primarily in the lower (62%) and upper (21%) extremities but may occur at any anatomic site [9], [10].

• br Conflicts of interest br Acknowledgements This work

  2021-01-21

  

  Conflicts of interest Acknowledgements This work was supported, in part or in whole, by the grants from the National Natural Science Foundation of China (11802056, 11772088), the China Postdoctoral Science Foundation (2018M640904), and the Fundamental Research Funds for the Central Universitie

• We continued to investigate the contribution of the

  2021-01-21

  

  We continued to investigate the contribution of the EP1 Triflusal to nociceptive sensitization by utilizing its natural ligand PGE and tested the effect of local subcutaneous injection of PGE (5nmol in 5μl) into one hindpaw on mechanical and heat pain thresholds. Wild-type mice displayed maximum se

14682 records 688/979 page Previous Next First page 上5页 686687688689690 下5页 Last page