• br GluR A knockout mice Genetically modified adult

  2021-10-14

  

  GluR-A knockout mice Genetically modified, adult mice lacking the GluR-A AMPA receptor subunit exhibit fast synaptic transmission in the hippocampus, mediated by the receptors formed from the remaining AMPA receptor subunits GluR-B and GluR-C (Sommer et al., 1991), but are deficient in a rapidly

• More recently Dal Peraro and coworkers

  2021-10-14

  

  More recently, Dal Peraro and coworkers [38] carried out 4 μs CG MD simulations of GS with six randomly placed C9915-55 peptides embedded into a synaptic plasma bilayer model. This lipid raft model was constituted by 32 different 2 deoxy d glucose and cholesterol (54.74%). In this study, the authors

• br Conclusion The histamine H

  2021-10-13

  

  Conclusion The histamine H3 receptor has been the focus of a great deal of research over the past four decades and in this context, substantial progress has been made in developing H3R-related ligands. The involvement of H3Rs in many neurological disorders has been documented by several lines of

• The metal nanoparticles of gold Au silver

  2021-10-13

  

  The metal nanoparticles of gold (Au), silver (Ag), Platinum (Pt), Palladium (Pd) and/or their composites are also being widely used to develop electrochemical sensors because of their unique advantages such as (i) ease in immobilization of receptor molecules, (ii) catalysis of electrochemical reacti

• br Conclusion br Funding br Availability of

  2021-10-13

  

  Conclusion Funding Availability of data and materials Authors' contributions Ethics approval and consent to participate Consent for publication Competing interests Introduction Hepatitis C virus (HCV) infection is a global public health problem. An estimated 71.1 million peop

• Reduction of the hydrolysis of ATP

  2021-10-13

  

  Reduction of the hydrolysis of ATP is an important strategy to reduce ischemia/reperfusion injury. Increased intracellular concentrations of solutes secondary to ATP depletion are known to result in osmotic swelling that may be sufficient to cause sarcolemmal rupture. Cinaciguat activates sGC direct

• Several reports have shown that

  2021-10-13

  

  Several reports have shown that the ICD of CLRs is involved in the desensitization process of this superfamily. The analysis of our chimeric constructs between GlyRα1 and GLIC revealed differences in desensitization properties. In contrast, other ion channel properties such as channel block and ion

• EAAT glutamate uptake is driven by

  2021-10-13

  

  EAAT glutamate uptake is driven by the co-transport of three sodium ions and one proton, as well as the counter-transport of one potassium ion (Fig. 1B). This complex stoichiometry frees up enough energy to permit XMD8-92 of glutamate into the cell against a steep concentration gradient. Additional

• br Hedgehog HH signaling plays an important role both during

  2021-10-13

  

  Hedgehog (HH) signaling plays an important role both during embryonic development and adult life. It is involved in the regulation of cell differentiation, cell proliferation and tissue polarity, as well as in the maintenance of stem cells, tissue repair, and regeneration (, ). Three ligands, Indi

• Irpex lacteus was well known

  2021-10-13

  

  Irpex lacteus was well known as an edible and medicinal mushroom. It had been reported that I. lacteus could produce a thermostable α-galactosidase [17]. The reported α-galactosidase from I. lacteus, however, seemed to be unsuitable for the practical application due to its poor hydrolysis ability to

• br Results The RAS MEK ERK

  2021-10-12

  

  Results The RAS/MEK/ERK pathway is a potential target of FGFR signaling. Indicative for its activation is the presence of double phosphorylated (activated) ERK (dpERK), which is generated in a series of phosphorylation events downstream of FGFR (op. cit. (Lemmon and Schlessinger, 2010)). Followin

• Recently the classical view of the compartmentalization of t

  2021-10-12

  

  Recently, the classical view of the compartmentalization of the plant isoprenoid metabolism has been re-evaluated, following the demonstration of the partial peroxisomal localization of the mevalonic Penciclovir Sodium (MVA) pathway, generally regarded as cytosolic. Using GFP-tagging approaches, th

• Previous studies have shown that inhibition of voltage gated

  2021-10-12

  

  Previous studies have shown that inhibition of voltage-gated Na+ SKF 81297 hydrobromide has a reduced effect on GABAergic boutons compared with other neurotransmitter phenotypes,46, 47 and voltage-gated Na+ channel subtypes are differentially expressed in hippocampus. In addition, SV exocytosis evok

• We have presented evidence that only muscle FBPase is detect

  2021-10-12

  

  We have presented evidence that only muscle FBPase is detectable within HL-1 cells. This is consistent with past findings of the Eschrich's group, which showed that in rat heart JNJ 5207852 dihydrochloride expression of FBPase is almost exclusively limited to the muscle isozyme [3]. Results of our

• Finally worth of mention are few papers that

  2021-10-12

  

  Finally, worth of mention are few papers that report on the discovery of HO-2 selective inhibitors. In 2013, starting from the screening of a tachykinins library, the above-mentioned Canadian research group identified Clemizole (Table 6) as a new hit compound for the development of the first series

15035 records 555/1003 page Previous Next First page 上5页 551552553554555 下5页 Last page