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Sorafenib was the first small RTK inhibitor drug
2023-11-02
Sorafenib was the first small RTK inhibitor drug to be developed and was initially approved against renal cell carcinoma, then against hepatocellular carcinoma (HCC) and more recently for differentiated thyroid treatment [111]. Sunitinib soon followed, being approved for gastrointestinal stromal tum
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Lubiprostone australia Exposure to B a P is an epidemiologic
2023-11-01
Exposure to B[a]P is an epidemiologically proven cause of lung cancer (Hecht, 2003; Rojas et al., 2004; Alexandrov et al., 2010), and the formation of B[a]PDE-N2-dG adducts is considered to be the critical event in lung tumorigenesis by B[a]P. On the other hand, there is evidence suggesting that the
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Introduction Glaucoma consists of a
2023-11-01
Introduction Glaucoma consists of a group of eye diseases showing a broad spectrum of clinical presentation and unknown aetiologies, that lead to a permanent loss of visual function due to the death of retinal ganglion mglur antagonist and damage of the optical nerve. It is well accepted that a cr
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Although the mechanisms of APP
2023-11-01
Although the mechanisms of APP secretion are well characterised (for review see Ref. [1]), production of soluble AChE species is less well understood although we have reported that a metalloproteinase can shed AChE similarly to APP [16], [17]. Recently it has also been demonstrated that cellular pr
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In conclusion we report that the
2023-11-01
In conclusion, we report that the widely prescribed drug VPA exerts therapeutic effects on optic nerve demyelination and retinal degeneration in a mouse model of MS. Our findings raise an interesting possibility that combination therapy of VPA and ASK1 inhibition may be useful for treatment of autoi
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Secondly leptin has been shown to
2023-11-01
Secondly, leptin has been shown to enhance aromatase mRNA expression, aromatase content and its enzymatic activity in epithelial breast cancer n-acetyl-l-cysteine mg by inducing promoters II and I.3 via an enhanced binding of transcription activator protein 1 (AP-1) complex to specific DNA sites in
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Recently competitive inhibitors of arginase
2023-11-01
Recently, competitive inhibitors of arginase have been developed which have greater specificity for the enzyme. Initial development of these compounds involved determination of the crystal structure of arginase. Christianson and colleagues found that a binuclear manganese cluster was required for ca
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br Genetic analysis of polarity complexes Model organisms
2023-11-01
Genetic analysis of polarity complexes Model organisms such as Caenorhabditis elegans and Drosophila melanogaster provide useful means of describing basic biological processes. They lend themselves particularly well to addressing some of the questions arising in this field because of their struc
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Idoxuridine Vascular interventional radiology VIR laboratori
2023-11-01
Vascular interventional radiology (VIR) laboratories perform a myriad of procedures ranging from simple tunneled peripherally inserted central catheter lines to complex transjugular intrahepatic portosystemic shunt placements. Infections are a common complication in the VIR environment; thus, the pr
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Platelet derived growth factor PDGF and ciliary
2023-10-31
Platelet-derived growth factor (PDGF) and ciliary neurotrophic factor (CNTF) are expressed by glial mao inhibitor and are important to neuron survival and the maintenance of oligodendrocytes. These neurotrophic factors contribute to the remyelination process by increasing the proliferation of oligo
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Disuflo Cy5 azide Blocking the action of CREB with the
2023-10-31
Blocking the action of CREB with the C646 inhibitor together with increasing Akt activation with the SC79 agonist is particularly interesting as it significantly reduced wound closure time from 7 days (which is required for complete closure of control hTECs exposed to DMSO) to only 4 days (when hTEC
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Extracellular adenosine acts as a local modulator
2023-10-31
Extracellular adenosine acts as a local modulator of cell function via four adenosine receptor subtypes (A1Rs A2AR, A2BR, and A3R) that are involved in numerous physiological and pathophysiological processes [31]. Each is encoded by a separate gene and has different functions, although with some ove
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An AXL decoy receptor with enhanced GAS
2023-10-31
An AXL decoy receptor with enhanced GAS6-binding properties, MYD1, was engineered as a therapeutic tool to disrupt GAS6/AXL signaling in vivo (Kariolis et al., 2014). MYD1 was shown to block metastasis of human ovarian cancer natural antibiotics and a murine breast cancer cell line in grafting assa
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In plants altered expression of
2023-10-31
In plants, altered expression of Aurora kinases results in impaired meiotic divisions followed by the formation of aneuploid or polyploid progenies [21]. This observation is interesting from an evolutionary point of view because it can be assumed that, during evolution, the influence of biotic and a
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br Conflict of interest br Acknowledgment The authors gratef
2023-10-31
Conflict of interest Acknowledgment The authors gratefully acknowledge the financial support from the National Natural Sciences Foundation of China (81070220 and 81170278), and the Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Human Provi
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